Journal
NANO LETTERS
Volume 20, Issue 7, Pages 5106-5110Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01305
Keywords
molecular imprinting; receptor; binding; molecular recognition; glycan; micelle
Categories
Funding
- NIGMS [R01GM113883]
Ask authors/readers for more resources
Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available