Journal
NANO LETTERS
Volume 20, Issue 9, Pages 6510-6519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c02248
Keywords
Carbohydrate-derived nanoparticles; Ischemia-reperfusion injury; Reactive oxygen species scavenging; Nanoantioxidant; Colloidal
Categories
Funding
- National Institutes of Health [R21EB027857, P30 CA014520]
- National Natural Science Foundation of China [51373128]
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Hepatic ischemia-reperfusion injury (IRI), which mainly results from excessive reactive oxygen species (ROS) generated by a reperfusion burst of oxygen, has long been a major cause of liver dysfunction and failure after surgical procedures. Here, a monodispersed hydrophilic carbohydrate-derived nanoparticle (C-NP) was synthesized as a nanoantioxidant that could effectively prevent hepatic IRI. The spherical C-NPs had a size of similar to 78 +/- 11.3 nm covered with polar surface groups. They were well dispersible in water with good colloidal stability, nontoxicity, and good ROS scavenging capability. The C-NPs also exhibited good circulation lifetime, effective delivery to liver, and gradual degradability with an ability to assist the IRI group maintaining a normal and healthy liver status. The pathology mechanism of C-NPs in hepatic IRI was confirmed to be scavenging of excessive ROS by C-NPs. The effective therapeutic treatment of C-NPs in living animals revealed a great potential in clinical prevention for hepatic IRI.
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