Journal
NANO LETTERS
Volume 20, Issue 7, Pages 5149-5158Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01371
Keywords
Injectable self-healing hydrogel; Insulin delivery; Redox homeostasis; Multidrug-resistant bacteria; Diabetic wound healing
Categories
Funding
- State Key Program of National Natural Science of China [51433008]
- Fundamental Research Funds for the Central Universities [3102017jc01001, 310201911fz051]
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Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed to simultaneously overcome these hurdles. The FEMI hydrogel was fabricated through a Schiff-based reaction between e-polylysine (EPL)-coated MnO2 nanosheets (EM) and insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through a synergistic combination of EPL and nanoknife-like MnO2 nanosheets, the FEMI hydrogel exhibited extraordinary antimicrobial capacities against MDR bacteria. The MnO2 nanoenzyme reshaped the hostile oxidative wound micro-environment by decomposing the endogenous H2O2 into O-2. Meanwhile, the pH/redox dual-responsive FEMI hydrogel achieved a sustained and spatiotemporal controlled release of insulin to regulate the blood glucose. Our FEMI hydrogel demonstrated an accelerated MDR bacteria-infected diabetic wound healing in vivo and represents a versatile strategy for healing a broad range of tissue damages caused by diabetes.
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