Journal
MYCOSES
Volume 63, Issue 10, Pages 1021-1032Publisher
WILEY
DOI: 10.1111/myc.13148
Keywords
breakthrough fungal infections; fungal infections; risk factors
Categories
Funding
- Oesterreichische Nationalbank (Anniversary Fund) [15346]
- National Institutes of Health [MH 113477, AI106039, AI036214, MH062512]
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The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has changed over the last few decades, partially due to the increased use of antifungal agents to prevent IFIs. Although this strategy has resulted in an overall reduction in IFIs, a subset of patients develop breakthrough IFIs with substantial morbidity and mortality in this population. Here, we review the most significant risk factors for breakthrough IFIs in haematology patients, solid organ transplant recipients, and patients in the intensive care unit, focusing particularly on host factors, and highlight areas that require future investigation.
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