Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 27, Issue 6, Pages 964-967Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458520948213
Keywords
Aquaporin-4; myelin oligodendrocyte glycoprotein; prevalence; adult
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Funding
- Korean Neurological Association [KNA-19-SK-12]
- Advanced Research Center Program of the National Research Foundation [NRF-2018R1A5A2023127]
- Korean Centers for Disease Control and Prevention [2020ER690100]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HC17C0078]
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In Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), the seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies was about five times lower than that of anti-aquaporin-4 (AQP4) antibodies.
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell-based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
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