Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 27, Issue 10, Pages 1477-1485Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458520936231
Keywords
Rehabilitation; early treatment; functional capacity; cognitive performance; deficits
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Impairments across multiple domains are a disabling consequence of multiple sclerosis (MS), with early detection of physical and cognitive deficits crucial for optimizing treatment strategies. Studies show significant impairments in MS/CIS patients even at early disease stages, highlighting the importance of early screening and interventions targeting multiple impaired domains.
Impairments across multiple domains are a disabling consequence of multiple sclerosis (MS). Originating from preventive medical strategies, the time matters-perspective has become a focal point when treating MS. In particular, early detection of physical and cognitive deficits, along with deficits in patient-reported outcomes seems crucial to further optimize both pharmacological and non-pharmacological MS treatment strategies. Therefore, this topical review investigates the level of impairments across multiple domains (physical function, cognitive function, and patient-reported outcomes) in the early stage of MS (<= 5 years since diagnosis, including clinically isolated syndrome (CIS)), when compared to matched healthy controls. Even at early disease stages, studies show impairments corresponding to 8%-34% and small-to-large numerical effect sizes (0.35-2.85) in MS/CIS patients across domains. This evidence call for early screening programs along with early interventions targeting the multiple impaired domains. This further highlights the importance of preventive initiatives preserving and/or restoring physical and cognitive reserve capacity if possible.
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