Parkinson's Disease,NOTCH3Genetic Variants, and White Matter Hyperintensities

Background White matter hyperintensities (WMH) on magnetic resonance imaging may influence clinical presentation in patients with Parkinson's disease (PD), although their significance and pathophysiological origins remain unresolved. Studies examining WMH have identified pathogenic variants inNOTCH3as an underlying cause of inherited forms of cerebral small vessel disease. Methods We examinedNOTCH3variants, WMH volumes, and clinical correlates in 139 PD patients in the Ontario Neurodegenerative Disease Research Initiative cohort. Results We identified 13 PD patients (similar to 9%) with rare (<1% of general population), nonsynonymousNOTCH3variants. Bayesian linear modeling demonstrated a doubling of WMH between variant negative and positive patients (3.1 vs. 6.9 mL), with large effect sizes for periventricular WMH (d= 0.8) and lacunes (d= 1.2). Negative correlations were observed between WMH and global cognition (r= -0.2). Conclusion TheNOTCH3rare variants in PD may significantly contribute to increased WMH burden, which in turn may negatively influence cognition. (c) 2020 International Parkinson and Movement Disorder Society