4.6 Article

Synthesis and Spectrophotometric Analysis of 1-Azafluorenone Derivatives

Journal

MOLECULES
Volume 25, Issue 15, Pages -

Publisher

MDPI
DOI: 10.3390/molecules25153358

Keywords

azafluorenone; synthesis; fluorescence

Funding

  1. National Institutes of Health [R15GM107702]
  2. Camille and Henry Dreyfus Foundation (Henry Dreyfus Teacher- Scholar Award)

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A new extension for the 'one pot' construction of diverse 1-azafluorene derivatives featuring a Diels-Alder/retro-Diels-Alder cycloaddition is reported. Conditions were also determined for oxidation to the derived azafluorenones. The spectrophotometric analysis of five different azafluorenones were performed. Moderate fluorescence was observed with azafluorenone derivatives that bear an imbedded pyridone motif; whereas those bearing substituted pyridines do not fluoresce.

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