Journal
MOLECULES
Volume 25, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules25133098
Keywords
saliva; volatile organic compounds (VOCs); oral diseases (ODs); biomarkers; analytical platforms
Funding
- FCT-Fundacao para a Ciencia e a Tecnologia through the CQM Base Fund [UIDB/00674/2020]
- FCT-Fundacao para a Ciencia e a Tecnologia through the Programmatic Fund [UIDP/00674/2020]
- ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao through Centro de Quimica da Madeira-CQM+ (Madeira 14-20 Program) [M142001-0145-FEDER-000005]
- Inno-INDIGO NCDs-CAPomics project, Department of Science & Technology, Govt. of India [DST/IMRCD/EU/Inno-Indigo/NCDs-CAPomics/2015]
- FCT [SFRH/BD/129630/2017]
- ARDITI [M1420-09-5369-FSE-000001]
- Inno-INDIGO NCDs-CAPomics Project [BMBF 01DQ16010]
Ask authors/readers for more resources
Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available