Journal
MOLECULES
Volume 25, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules25133050
Keywords
injectable hydrogel; triple dynamic bonds; natural polysaccharide derivatives; biocompatible; stimuli-responsive
Funding
- National Natural Science Foundation of China (NSFC) [U1733130, 11704244]
- Shanghai Natural Science Funding [17ZR1441000]
- Shanghai Science and Technology Innovation Action Plan [18511109000]
- Joint Fund of the Education Ministry of China [6141A02022264]
- Medical-Engineering Cross Research Funding of SJTU [YG2017MS01, YG2016QN34]
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Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3 '-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.
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