4.6 Review

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

delta-Secretase-cleaved Tau stimulates A beta production via upregulating STAT1-BACE1 signaling in Alzheimer's disease

Zhentao Zhang et al.

Summary: This study reveals that the fragments generated by delta-secretase cleavage, APP and Tau, act additively to drive AD pathogenesis and cognitive dysfunctions. Tau(1-368) fragment enhances BACE1 expression and A beta generation, and has a more robust effect than full-length Tau, promoting the nuclear translocation of active STAT1 and increasing BACE1 and A beta production. Further mechanism involving A beta-activated kinases phosphorylating STAT1 and its association with Tau(1-368) is also discussed.

MOLECULAR PSYCHIATRY (2021)

Editorial Material Clinical Neurology

A resurrection of aducanumab for Alzheimer's disease

Lon Schneider

LANCET NEUROLOGY (2020)

Review Clinical Neurology

Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways

Steven M. Greenberg et al.

NATURE REVIEWS NEUROLOGY (2020)

Review Neurosciences

Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer's Disease

Xiaohua Zhang et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis

Julia J. Schubert et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

Article Multidisciplinary Sciences

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Jerrah K. Holth et al.

SCIENCE (2019)

Review Geriatrics & Gerontology

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease

Celia G. Fernandez et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Neurosciences

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Jorge L. Del-Aguila et al.

MOLECULAR NEURODEGENERATION (2019)

Letter Medicine, General & Internal

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease

David Henley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease

Michael F. Egan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Nicolai Franzmeier et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Metal Ions in Alzheimer's Disease: A Key Role or Not?

Yan Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Neurosciences

TREM2 function impedes tau seeding in neuritic plaques

Cheryl E. G. Leyns et al.

NATURE NEUROSCIENCE (2019)

Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yu Yamazaki et al.

NATURE REVIEWS NEUROLOGY (2019)

Review Toxicology

Management of oxidative stress and other pathologies in Alzheimer's disease

Miriama Simunkova et al.

ARCHIVES OF TOXICOLOGY (2019)

Review Microbiology

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Yiliang Wanga et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2019)

Review Clinical Neurology

Neuropeptides in Alzheimer's Disease: An Update

Carla Petrella et al.

CURRENT ALZHEIMER RESEARCH (2019)

Article Clinical Neurology

Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer's disease

Michael F. Egan et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

Review Biochemistry & Molecular Biology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

Article Neurosciences

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease

Carol J. Huseby et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Biochemistry & Molecular Biology

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report

Joseph F. Arboleda-Velasquez et al.

NATURE MEDICINE (2019)

Article Neurosciences

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

Annika Behrendt et al.

NEUROBIOLOGY OF DISEASE (2019)

Review Physiology

BLOOD-BRAIN BARRIER: FROM PHYSIOLOGY TO DISEASE AND BACK

Melanie D. Sweeney et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Neurosciences

It's all about tau

Cheril Tapia-Rojas et al.

PROGRESS IN NEUROBIOLOGY (2019)

Article Multidisciplinary Sciences

Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging

Danielle Beckman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research

Konstantina G. Yiannopoulou et al.

BIOMEDICINES (2019)

Review Clinical Neurology

Neuroinflammatory responses in Alzheimer's disease

Cira Dansokho et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Article Biochemistry & Molecular Biology

Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation

Y. Akwa et al.

MOLECULAR PSYCHIATRY (2018)

Correction Clinical Neurology

2018 Alzheimer's Disease Facts and Figures (vol 14, pg 367, 2018)

ALZHEIMERS & DEMENTIA (2018)

Article Clinical Neurology

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

Constantinos D. Paspalas et al.

ALZHEIMERS & DEMENTIA (2018)

Article Clinical Neurology

Effect of Sleep on Overnight Cerebrospinal Fluid Amyloid beta Kinetics

Brendan P. Lucey et al.

ANNALS OF NEUROLOGY (2018)

Article Multidisciplinary Sciences

Revisiting the genomic hypomethylation hypothesis of aging

Archana Unnikrishnan et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

Review Biochemistry & Molecular Biology

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Aleksandra Deczkowska et al.

Article Neurosciences

Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease

Tara E. Tracy et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease

Cheng Gu et al.

DNA AND CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Tau protein liquid-liquid phase separation can initiate tau aggregation

Susanne Wegmann et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Acetylation Disfavors Tau Phase Separation

Josephine C. Ferreon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Francesc X. Guix et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Neurosciences

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

James P. Quinn et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Immunology

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

Wilbur M. Song et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Pathology

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

Benjamin A. Plog et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Neurosciences

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Joseph McInnes et al.

NEURON (2018)

Article Multidisciplinary Sciences

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Yujun Hou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Normal aging induces A1-like astrocyte reactivity

Laura E. Clarke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Near-atomic model of microtubule-tau interactions

Elizabeth H. Kellogg et al.

SCIENCE (2018)

Review Clinical Neurology

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis

Le Shi et al.

SLEEP MEDICINE REVIEWS (2018)

Article Multidisciplinary Sciences

A transcriptomic atlas of aged human microglia

Marta Olah et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

Taxiarchis Katsinelos et al.

CELL REPORTS (2018)

Review Neurosciences

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Ying Cheng et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Article Immunology

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

Heidi Martini-Stoica et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Neurosciences

PU.1 regulates Alzheimer's disease-associated genes in primary human microglia

Justin Rustenhoven et al.

MOLECULAR NEURODEGENERATION (2018)

Article Cell Biology

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Ming-Hsuan Ou-Yang et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Multidisciplinary Sciences

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

Jennifer N. Rauch et al.

SCIENTIFIC REPORTS (2018)

Review Neurosciences

New insights into the role of TREM2 in Alzheimer's disease

Maud Gratuze et al.

MOLECULAR NEURODEGENERATION (2018)

Article Multidisciplinary Sciences

APOE ε2 is associated with increased tau pathology in primary tauopathy

Na Zhao et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

Hsu-Hsin Chen et al.

SCIENTIFIC REPORTS (2018)

Article Cell Biology

Secretion of Tau via an Unconventional Non-vesicular Mechanism

Maria Merezhko et al.

CELL REPORTS (2018)

Review Geriatrics & Gerontology

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease

Ruth F. Itzhaki

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Clinical Neurology

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

Atsuko Katsumoto et al.

FRONTIERS IN NEUROLOGY (2018)

Article Biochemistry & Molecular Biology

Young microglia restore amyloid plaque clearance of aged microglia

Anna Daria et al.

EMBO JOURNAL (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Medicine, Research & Experimental

Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells

Li Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Review Neurosciences

The Gut Microbiota and Alzheimer's Disease

Chunmei Jiang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

Eric Tonnies et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Immunology

SOR LA attenuates EphA4 signaling and amyloid β-induced neurodegeneration

Timothy Y. Huang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Immunology

Tau deletion promotes brain insulin resistance

Elodie Marciniak et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Neurosciences

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Chia-Chen Liu et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

Absence of CX3CR1 impairs the internalization of Tau by microglia

Marta Bolos et al.

MOLECULAR NEURODEGENERATION (2017)

Article Neurosciences

The release and trans-synaptic transmission of Tau via exosomes

Yipeng Wang et al.

MOLECULAR NEURODEGENERATION (2017)

Article Multidisciplinary Sciences

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Joseph M. Castellano et al.

NATURE (2017)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Article Neurosciences

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Thais F. Galatro et al.

NATURE NEUROSCIENCE (2017)

Article Neurosciences

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Chia-Chen Liu et al.

NEURON (2017)

Article Multidisciplinary Sciences

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Cheryl E. G. Leyns et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Neurosciences

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

Jesse S. Kerr et al.

TRENDS IN NEUROSCIENCES (2017)

Article Multidisciplinary Sciences

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease

Zhentao Zhang et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

Susmitha Ambadipudi et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Tau association with synaptic vesicles causes presynaptic dysfunction

Lujia Zhou et al.

NATURE COMMUNICATIONS (2017)

Article Neurosciences

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Sarah K. Kaufman et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

T. Harach et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Review Clinical Neurology

Tau and neurodegenerative disease: the story so far

Khalid Iqbal et al.

NATURE REVIEWS NEUROLOGY (2016)

Article Clinical Neurology

2016 Alzheimer's disease facts and figures

Alzheimers & Dementia (2016)

Article Biochemistry & Molecular Biology

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Donna M. Wilcock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Article Biochemistry & Molecular Biology

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Amy R. Nelson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Editorial Material Biology

Q&A: What are exosomes, exactly?

James R. Edgar

BMC BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Microglia in central nervous system repair after injury

Xuemei Jin et al.

JOURNAL OF BIOCHEMISTRY (2016)

Review Nutrition & Dietetics

Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes

Allison Clark et al.

JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2016)

Article Clinical Neurology

Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

Panagiotis Fotiadis et al.

LANCET NEUROLOGY (2016)

Article Neurosciences

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Erica Barini et al.

MOLECULAR NEURODEGENERATION (2016)

Article Biochemistry & Molecular Biology

Caspase-2 cleavage of tau reversibly impairs memory

Xiaohui Zhao et al.

NATURE MEDICINE (2016)

Article Neurosciences

Neuronal activity enhances tau propagation and tau pathology in vivo

Jessica W. Wu et al.

NATURE NEUROSCIENCE (2016)

Review Biotechnology & Applied Microbiology

Calpain research for drug discovery: challenges and potential

Yasuko Ono et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Neurosciences

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Weiguo Peng et al.

NEUROBIOLOGY OF DISEASE (2016)

Review Clinical Neurology

Dysfunction of NMDA receptors in Alzheimer's disease

Yan Zhang et al.

NEUROLOGICAL SCIENCES (2016)

Article Neurosciences

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

Kathleen M. Schoch et al.

NEURON (2016)

Article Biology

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

Paul Alan Cox et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Article Multidisciplinary Sciences

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice

Arne Ittner et al.

SCIENCE (2016)

Article

Twenty-five years of the amyloid hypothesis of alzheimer disease: advances, failures and new perspectives

O. S. Levin et al.

Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova (2016)

Article Multidisciplinary Sciences

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Y. Iturria-Medina et al.

NATURE COMMUNICATIONS (2016)

Article Clinical Neurology

Safety and tolerability of BAN2401-a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody

Veronika Logovinsky et al.

ALZHEIMERS RESEARCH & THERAPY (2016)

Article Cell Biology

Loss of Bin1 Promotes the Propagation of Tau Pathology

Sara Calafate et al.

CELL REPORTS (2016)

Review Geriatrics & Gerontology

Tau Structures

Jesus Avila et al.

FRONTIERS IN AGING NEUROSCIENCE (2016)

Article Clinical Neurology

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Jinte Middeldorp et al.

JAMA NEUROLOGY (2016)

Review Medicine, General & Internal

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Urmi Sengupta et al.

EBIOMEDICINE (2016)

Article Neurosciences

LRP1 expression in microglia is protective during CNS autoimmunity

Tzu-Ying Chuang et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Neurosciences

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

Meryem Tardivel et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Neurosciences

Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations

Hui-Zhen Wang et al.

MOLECULAR NEUROBIOLOGY (2016)

Article Multidisciplinary Sciences

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

Marianna Karina Gorsky et al.

SCIENTIFIC REPORTS (2016)

Article Clinical Neurology

Coding Mutations in SORL1 and Alzheimer Disease

Badri N. Vardarajan et al.

ANNALS OF NEUROLOGY (2015)

Article Clinical Neurology

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

Adam C. Kaufman et al.

ANNALS OF NEUROLOGY (2015)

Review Immunology

Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update

Zhi-Gang Zhang et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2015)

Letter Immunology

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

Lieve Desbonnet et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Article Biochemistry & Molecular Biology

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Jessica M. Yano et al.

Review Biochemistry & Molecular Biology

Establishment and Dysfunction of the Blood-Brain Barrier

Zhen Zhao et al.

Article Biochemistry & Molecular Biology

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model

Yaming Wang et al.

Review Cell Biology

Neuronal cell cycle: the neuron itself and its circumstances

Jose M. Frade et al.

CELL CYCLE (2015)

Article Biochemistry & Molecular Biology

The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties

Shin-Ei Matsumoto et al.

HUMAN MOLECULAR GENETICS (2015)

Article Cell Biology

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

Keith A. Vossel et al.

JOURNAL OF CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

Sophie Sokolow et al.

JOURNAL OF NEUROCHEMISTRY (2015)

Article Neurosciences

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

Philip Regan et al.

JOURNAL OF NEUROSCIENCE (2015)

Review Cell Biology

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease

Sim K. Singhrao et al.

MEDIATORS OF INFLAMMATION (2015)

Article Neurosciences

Analysis of in vivo turnover of tau in a mouse model of tauopathy

Kaoru Yamada et al.

MOLECULAR NEURODEGENERATION (2015)

Article Neurosciences

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

Zhiqiang Xu et al.

MOLECULAR NEURODEGENERATION (2015)

Review Neurosciences

Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik et al.

MOLECULAR NEURODEGENERATION (2015)

Article Multidisciplinary Sciences

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Michael Willem et al.

NATURE (2015)

Article Multidisciplinary Sciences

Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Sang-Won Min et al.

NATURE MEDICINE (2015)

Article Neurosciences

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai et al.

NATURE NEUROSCIENCE (2015)

Review Clinical Neurology

Clearance systems in the brain-implications for Alzheimer disease

Jenna M. Tarasoff-Conway et al.

NATURE REVIEWS NEUROLOGY (2015)

Review Neurosciences

Astrocyte barriers to neurotoxic inflammation

Michael V. Sofroniew

NATURE REVIEWS NEUROSCIENCE (2015)

Article Endocrinology & Metabolism

Stress, the Stress System and the Role of Glucocorticoids

Nicolas C. Nicolaides et al.

NEUROIMMUNOMODULATION (2015)

Article Clinical Neurology

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

Patricia A. Boyle et al.

NEUROLOGY (2015)

Article Neurosciences

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

Axel Montagne et al.

NEURON (2015)

Review Pharmacology & Pharmacy

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

Eleonore Beurel et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Multidisciplinary Sciences

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

Harindranath Kadavath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Clinical Neurology

Conversion of psychological stress into cellular stress response: Roles of the sigma-1 receptor in the process

Teruo Hayashi

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2015)

Review Clinical Neurology

Cerebral Amyloid Angiopathy: Emerging Concepts

Masahito Yamada

JOURNAL OF STROKE (2015)

Review Neurosciences

The Role of SORL1 in Alzheimer's Disease

Rui-Hua Yin et al.

MOLECULAR NEUROBIOLOGY (2015)

Review Neurosciences

Axonal Transport Defects in Alzheimer's Disease

Zi-Xuan Wang et al.

MOLECULAR NEUROBIOLOGY (2015)

Article Neurosciences

Herpes Viruses Increase the Risk of Alzheimer's Disease: A Meta-Analysis

Ariah J. Steel et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Neurosciences

A Phase II Trial of Tideglusib in Alzheimer's Disease

Simon Lovestone et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Clinical Neurology

Primary age-related tauopathy (PART): a common pathology associated with human aging

John F. Crary et al.

ACTA NEUROPATHOLOGICA (2014)

Article Biochemistry & Molecular Biology

Amyloid-β(1-42) protofibrils stimulate a quantum of secreted IL-1β despite significant intracellular IL-1β accumulation in microglia

Shana E. Terrill-Usery et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

March separate, strike together - Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

Anne Eckert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Biochemistry & Molecular Biology

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

Katharina Flach et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

Russell H. Swerdlow et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

Xinglong Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Pharmacology & Pharmacy

Preventing cognitive decline in preclinical Alzheimer's disease

Wim J. Riedel

CURRENT OPINION IN PHARMACOLOGY (2014)

Review Neurosciences

Functional regeneration beyond the glial scar

Jared M. Cregg et al.

EXPERIMENTAL NEUROLOGY (2014)

Article Gastroenterology & Hepatology

Microbiota and diabetes: an evolving relationship

Herbert Tilg et al.

Article Biochemistry & Molecular Biology

Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model

Wenjuan Zhao et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

Casey Cook et al.

HUMAN MOLECULAR GENETICS (2014)

Review Biochemistry & Molecular Biology

Apolipoprotein E Isoforms and Lipoprotein Metabolism

Michael C. Phillips

IUBMB LIFE (2014)

Article Biochemistry & Molecular Biology

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

Claire H. Michel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Immunology

Neuronal activity regulates extracellular tau in vivo

Kaoru Yamada et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Biochemistry & Molecular Biology

Nucleic acid oxidation: an early feature of Alzheimer's disease

Melissa A. Bradley-Whitman et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Saul A. Villeda et al.

NATURE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhentao Zhang et al.

NATURE MEDICINE (2014)

Article Geriatrics & Gerontology

Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion

Tariq Ahmed et al.

NEUROBIOLOGY OF AGING (2014)

Article Endocrinology & Metabolism

Improved memory function two years after bariatric surgery

Michael L. Alosco et al.

OBESITY (2014)

Article Biology

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Tetsuya Kimura et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Article Multidisciplinary Sciences

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

Hong-Bin Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

Amy K. Y. Fu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Geriatrics & Gerontology

Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus

Ruth F. Itzhaki

FRONTIERS IN AGING NEUROSCIENCE (2014)

Article Clinical Neurology

Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis

George S. Bloom

JAMA NEUROLOGY (2014)

Article Neurosciences

Modulation of tau phosphorylation by environmental copper

Kellen Voss et al.

TRANSLATIONAL NEURODEGENERATION (2014)

Article Clinical Neurology

The sleep-wake cycle and Alzheimer's disease: what do we know?

Miranda M. Lim et al.

NEURODEGENERATIVE DISEASE MANAGEMENT (2014)

Article Psychology, Developmental

Beyond allostatic load: Rethinking the role of stress in regulating human development

Bruce J. Ellis et al.

DEVELOPMENT AND PSYCHOPATHOLOGY (2014)

Article Biochemical Research Methods

Probing copper/tau protein interactions electrochemically

Sanela Martic et al.

ANALYTICAL BIOCHEMISTRY (2013)

Review Endocrinology & Metabolism

Roles of the calcium sensing receptor in the central nervous system

Martial Ruat et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Biochemistry & Molecular Biology

Physiological release of endogenous tau is stimulated by neuronal activity

Amy M. Pooler et al.

EMBO REPORTS (2013)

Article Biochemistry & Molecular Biology

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

Jessica W. Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Medicine, Research & Experimental

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

Tae-In Kam et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Neurosciences

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Raasay S. Jones et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)

Article Clinical Neurology

Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

Jasmine Ramcharitar et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Neurosciences

Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Takahisa Kanekiyo et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

J. Chapuis et al.

MOLECULAR PSYCHIATRY (2013)

Article Multidisciplinary Sciences

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka et al.

NATURE (2013)

Article Multidisciplinary Sciences

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

Article Genetics & Heredity

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert et al.

NATURE GENETICS (2013)

Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Chia-Chan Liu et al.

NATURE REVIEWS NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

The microtubule-associated tau protein has intrinsic acetyltransferase activity

Todd J. Cohen et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer's Disease

Jere E. Meredith et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

Lu Wang et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Maria Talantova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Brandon B. Holmes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Editorial Material Multidisciplinary Sciences

Promiscuous Alzheimer's Amyloid: Yet Another Partner

Iryna Benilova et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie et al.

SCIENCE (2013)

Review Cell Biology

MicroRNAs and neurodegeneration: role and impact

Masashi Abe et al.

TRENDS IN CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

Andrew J. Nicoll et al.

NATURE COMMUNICATIONS (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Article Clinical Neurology

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

Denise Head et al.

ARCHIVES OF NEUROLOGY (2012)

Article Biochemistry & Molecular Biology

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

Ilaria Lamberto et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

Tau oligomers and tau toxicity in neurodegenerative disease

Sarah M. Ward et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2012)

Review Pharmacology & Pharmacy

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

Wojciech Danysz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Editorial Material Neurosciences

The role of astrocytes in amyloid β-protein toxicity and clearance

Dietmar Rudolf Thal

EXPERIMENTAL NEUROLOGY (2012)

Article Biochemistry & Molecular Biology

Ephs and ephrins: Emerging therapeutic targets in neuropathology

Benjamin K. Attwood et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

Ismael Santa-Maria et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Endocrinology & Metabolism

CD36 is involved in astrocyte activation and astroglial scar formation

Yi Bao et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Review Biochemistry & Molecular Biology

Glial cells in (patho)physiology

Vladimir Parpura et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Neurosciences

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Yonghao Zhao et al.

MOLECULAR NEURODEGENERATION (2012)

Article Neurosciences

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

Juan D. Pita-Almenar et al.

LEARNING & MEMORY (2012)

Article Multidisciplinary Sciences

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline

Thorlakur Jonsson et al.

NATURE (2012)

Article Multidisciplinary Sciences

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Robert D. Bell et al.

NATURE (2012)

Article Multidisciplinary Sciences

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Johannes Graeff et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei et al.

NATURE MEDICINE (2012)

Article Geriatrics & Gerontology

Apolipoprotein E ε4-related thickening of the cerebral cortex modulates selective attention

Thomas Espeseth et al.

NEUROBIOLOGY OF AGING (2012)

Article Geriatrics & Gerontology

Sodium intake and physical activity impact cognitive maintenance in older adults: the NuAge Study

Alexandra J. Fiocco et al.

NEUROBIOLOGY OF AGING (2012)

Article Neurosciences

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

Alix de Calignon et al.

NEURON (2012)

Article Multidisciplinary Sciences

Trans-Synaptic Spread of Tau Pathology In Vivo

Li Liu et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Expression of Novel Alzheimer's Disease Risk Genes in Control and Alzheimer's Disease Brains

Celeste M. Karch et al.

PLOS ONE (2012)

Article Medicine, Research & Experimental

The Genetics of Alzheimer Disease

Rudolph E. Tanzi

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Rawan Tarawneh et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Neurosciences

Soluble forms of tau are toxic in Alzheimer's disease

Katherine J. Kopeikina et al.

TRANSLATIONAL NEUROSCIENCE (2012)

Article Geriatrics & Gerontology

Vulnerability to Stress, Anxiety, and Development of Dementia in Old Age

Robert S. Wilson et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2011)

Article Pathology

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

Alberto Serrano-Pozo et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Biochemistry & Molecular Biology

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

Scott A. Yuzwa et al.

AMINO ACIDS (2011)

Review Neurosciences

Amyloid Precursor Protein Processing and Alzheimer's Disease

Richard J. O'Brien et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Article Clinical Neurology

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

Christiane Reitz et al.

ARCHIVES OF NEUROLOGY (2011)

Article Clinical Neurology

CSF amyloid β38 as a novel diagnostic marker for dementia with Lewy bodies

Ezra Mulugeta et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)

Article Clinical Neurology

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

Heiko Braak et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Review Clinical Neurology

Apolipoprotein E in Alzheimer's disease and other neurological disorders

Philip B. Verghese et al.

LANCET NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple Tauopathies

Adriana Ferreira et al.

MOLECULAR MEDICINE (2011)

Article Multidisciplinary Sciences

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

Moustapha Cisse et al.

NATURE (2011)

Review Neurosciences

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Berislav V. Zlokovic

NATURE REVIEWS NEUROSCIENCE (2011)

Article Cell Biology

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

Mark A. Lovell et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2011)

Article Geriatrics & Gerontology

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

Sarika Garg et al.

NEUROBIOLOGY OF AGING (2011)

Article Gastroenterology & Hepatology

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

K. M. Neufeld et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2011)

Article Biochemistry & Molecular Biology

Insoluble cellular prion protein and its association with prion and Alzheimer diseases

Wen-Quan Zou et al.

PRION (2011)

Article Multidisciplinary Sciences

Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

John R. Cirrito et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Todd J. Cohen et al.

NATURE COMMUNICATIONS (2011)

Review Neurosciences

APP processing in Alzheimer's disease

Yun-Wu Zhang et al.

MOLECULAR BRAIN (2011)

Article Clinical Neurology

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

Alessandro Biffi et al.

ARCHIVES OF NEUROLOGY (2010)

Review Biochemistry & Molecular Biology

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease

D. Allan Butterfield et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Paula I. Moreira et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Review Clinical Neurology

Rational therapeutic approaches to progressive supranuclear palsy

Maria Stamelou et al.

BRAIN (2010)

Article Biochemistry & Molecular Biology

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Lars M. Ittner et al.

Article Biochemistry & Molecular Biology

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

Hirokazu Okada et al.

FASEB JOURNAL (2010)

Review Neurosciences

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

Gary E. Gibson et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Neurosciences

Neuron Specific Toxicity of Oligomeric Amyloid-beta: Role for JUN-Kinase and Oxidative Stress

Philip J. Ebenezer et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Neurosciences

Interneuronal Transfer of Human Tau Between Lamprey Central Neurons in situ

WonHee Kim et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Biochemistry & Molecular Biology

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

Eugene L. Kang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Neurosciences

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

David A. Gimbel et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

Xiangyou Hu et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

Deletion of Tau Attenuates Heat Shock-Induced Injury in Cultured Cortical Neurons

Yanying Miao et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2010)

Review Neurosciences

Diverse Roles of Extracellular Calcium-Sensing Receptor in the Central Nervous System

Sanghamitra Bandyopadhyay et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2010)

Article Biochemical Research Methods

Analysis of Human Tau in Cerebrospinal Fluid

Katja Hanisch et al.

JOURNAL OF PROTEOME RESEARCH (2010)

Article Multidisciplinary Sciences

Caspase activation precedes and leads to tangles

Alix de Calignon et al.

NATURE (2010)

Article Multidisciplinary Sciences

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Shahaf Peleg et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport

Keith A. Vossel et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

TREM2-and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

Qisheng Peng et al.

SCIENCE SIGNALING (2010)

Review Chemistry, Multidisciplinary

Mysterious alpha 6-containing nAChRs: function, pharmacology, and pathophysiology

Ke-chun Yang et al.

ACTA PHARMACOLOGICA SINICA (2009)

Review Biochemistry & Molecular Biology

Calcium-Sensing Receptor (CaSR) in Human Brain's Pathophysiology: Roles in Late-Onset Alzheimer's Disease (LOAD)

Anna Chiarini et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2009)

Article Geriatrics & Gerontology

Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer's Disease

Hsin-Ping Liu et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)

Article Biochemistry & Molecular Biology

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

Bess Frost et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Clinical Neurology

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer's disease

Volker Welge et al.

JOURNAL OF NEURAL TRANSMISSION (2009)

Article Biochemistry & Molecular Biology

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

Masashi Kitazawa et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Neurosciences

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Xinglong Wang et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

HDAC2 negatively regulates memory formation and synaptic plasticity

Ji-Song Guan et al.

NATURE (2009)

Article Multidisciplinary Sciences

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Anatoly Nikolaev et al.

NATURE (2009)

Article Cell Biology

Transmission and spreading of tauopathy in transgenic mouse brain

Florence Clavaguera et al.

NATURE CELL BIOLOGY (2009)

Article Neurosciences

Olfactory behavior and physiology are disrupted in prion protein knockout mice

Claire E. Le Pichon et al.

NATURE NEUROSCIENCE (2009)

Review Biotechnology & Applied Microbiology

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Kurt R. Brunden et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biochemistry & Molecular Biology

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

J. Cameron Thrash et al.

NEUROCHEMICAL RESEARCH (2009)

Article Neurosciences

Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

Simon Paine et al.

NEUROSCIENCE LETTERS (2009)

Review Pharmacology & Pharmacy

Alzheimer's disease, metal ions and metal homeostatic therapy

Paolo Zatta et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Article Pathology

Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes

Jeffrey A. Fein et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

Article Psychiatry

Brain reserve and the prevention of dementia

Michael J. Valenzuela

CURRENT OPINION IN PSYCHIATRY (2008)

Review Neurosciences

Amyloid beta peptides and glutamatergic synaptic dysregulation

Kodeeswaran Parameshwaran et al.

EXPERIMENTAL NEUROLOGY (2008)

Review Neurosciences

Tau exon 10 alternative splicing and tauopathies

Fei Liu et al.

MOLECULAR NEURODEGENERATION (2008)

Article Biochemistry & Molecular Biology

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Scott A. Yuzwa et al.

NATURE CHEMICAL BIOLOGY (2008)

Article Immunology

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle et al.

NATURE IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar et al.

NATURE MEDICINE (2008)

Article Neurosciences

Is there a link between sleep changes and memory in Alzheimer's disease?

Geraldine Rauchs et al.

NEUROREPORT (2008)

Review Physiology

Physiology of the prion protein

Rafael Linden et al.

PHYSIOLOGICAL REVIEWS (2008)

Article Multidisciplinary Sciences

Differential regulation of dynein and kinesin motor proteins by tau

Ram Dixit et al.

SCIENCE (2008)

Review Clinical Neurology

Alzheimer disease models and human neuropathology: similarities and differences

Charles Duyckaerts et al.

ACTA NEUROPATHOLOGICA (2008)

Article Biochemistry & Molecular Biology

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimers disease

Mark A. Lovell et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

Single molecule profiling of tau gene expression in Alzheimer's disease

Chris Conrad et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Neurosciences

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

Toshifumi Matsui et al.

BRAIN RESEARCH (2007)

Article Biochemistry & Molecular Biology

Validation of amyloid-β peptides in CSF diagnosis of neurodegenerative dementias

M. Bibl et al.

MOLECULAR PSYCHIATRY (2007)

Article Neurosciences

Depletion of GGA3 stabilizes BACE and enhances β-secretase activity

Giuseppina Tesco et al.

NEURON (2007)

Article Genetics & Heredity

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva et al.

NATURE GENETICS (2007)

Review Biochemistry & Molecular Biology

A beta Oligomers - a decade of discovery

Dominic M. Walsh et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Geriatrics & Gerontology

Serum magnesium level and clinical deterioration in Alzheimer's disease

Asli Ece Cilliler et al.

GERONTOLOGY (2007)

Article Endocrinology & Metabolism

Neuroprotective effect of exogenous microglia in global brain ischemia

Fumihiro Imai et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Review Cell Biology

NMDA receptor function:: subunit composition versus spatial distribution

Georg Koehr

CELL AND TISSUE RESEARCH (2006)

Review Geriatrics & Gerontology

Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease

Alessia D'Introno et al.

NEUROBIOLOGY OF AGING (2006)

Review Biochemistry & Molecular Biology

Apolipoprotein E structure: insights into function

Danny M. Hatters et al.

TRENDS IN BIOCHEMICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein

V Dorval et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Neurosciences

Toll-like receptors in central nervous system glial inflammation and homeostasis

T Kielian

JOURNAL OF NEUROSCIENCE RESEARCH (2006)

Article Multidisciplinary Sciences

Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease

JP Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Psychiatry

Role of genes and environments for explaining Alzheimer disease

M Gatz et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

Article Public, Environmental & Occupational Health

Education and dementia: A meta-analytic study

Francisco Caamano-Isorna et al.

NEUROEPIDEMIOLOGY (2006)

Article Multidisciplinary Sciences

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

OM Andersen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Neurosciences

Regulation of NMDA receptor trafficking by amyloid-β

EM Snyder et al.

NATURE NEUROSCIENCE (2005)

Article Multidisciplinary Sciences

Tau suppression in a neurodegenerative mouse model improves memory function

K SantaCruz et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Sites of tau important for aggregation populate β-structure and bind to microtubules and polyanions

MD Mukrasch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

JR Babu et al.

JOURNAL OF NEUROCHEMISTRY (2005)

Article Neurosciences

Quantitative analysis of tau isoform transcripts in sporadic tauopathies

JW Connell et al.

MOLECULAR BRAIN RESEARCH (2005)

Article Geriatrics & Gerontology

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

L Mighore et al.

NEUROBIOLOGY OF AGING (2005)

Article Multidisciplinary Sciences

Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

JC Dodart et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

BT Hyman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)

Article Multidisciplinary Sciences

ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease

JW Lustbader et al.

SCIENCE (2004)

Article Clinical Neurology

Altered expression levels of the protein phosphatase 2A ABαC enzyme are associated with Alzheimer disease pathology

E Sontag et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)

Article Biochemistry & Molecular Biology

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

L Petrucelli et al.

HUMAN MOLECULAR GENETICS (2004)

Article Cell Biology

Calcium-sensing receptor in the brain

S Yano et al.

CELL CALCIUM (2004)

Article Neurosciences

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease

PM Horowitz et al.

JOURNAL OF NEUROSCIENCE (2004)

Article Medicine, Research & Experimental

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

RA Rissman et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Biochemistry & Molecular Biology

Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

M Necula et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Neurosciences

Eph receptors in the adult brain

Y Yamaguchi et al.

CURRENT OPINION IN NEUROBIOLOGY (2004)

Article Biochemistry & Molecular Biology

The LPS receptor (CD14) links innate immunity with Alzheimer's disease

K Fassbender et al.

FASEB JOURNAL (2004)

Article Biochemistry & Molecular Biology

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice

P May et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biotechnology & Applied Microbiology

Alzheimer's missing link?

[Anonymous]

MOLECULAR THERAPY (2003)

Article Multidisciplinary Sciences

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

TC Gamblin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Cell Biology

Extracellular calcium sensing and signalling

AM Hofer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Immunology

CD36 mediates the innate host response to β-amyloid

JB El Khoury et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Biochemistry & Molecular Biology

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

T Wyss-Coray et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

S Keck et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Article Biochemistry & Molecular Biology

A CD36-initiated signaling cascade mediates inflammatory effects of β-amyloid

KJ Moore et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

CD Schmid et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

HC Tseng et al.

FEBS LETTERS (2002)

Review Cell Biology

Mechanisms and functions of EPH and ephrin signalling

K Kullander et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Tau is essential to β-amyloid-induced neurotoxicity

M Rapoport et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease

F Liu et al.

FEBS LETTERS (2002)

Article Neurosciences

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease

Khalid Iqbal et al.

JOURNAL OF ALZHEIMERS DISEASE (2002)

Article Biochemistry & Molecular Biology

GlutamateNMDA receptor NR1 subunit mRNA expression in Alzheimer's disease

MR Hynd et al.

JOURNAL OF NEUROCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Tau-66:: evidence for a novel tau conformation in Alzheimer's disease

N Ghoshal et al.

JOURNAL OF NEUROCHEMISTRY (2001)

Review Neurosciences

NMDA receptor subunits: diversity, development and disease

S Cull-Candy et al.

CURRENT OPINION IN NEUROBIOLOGY (2001)

Article Neurosciences

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

V Vogelsberg-Ragaglia et al.

EXPERIMENTAL NEUROLOGY (2001)

Article Clinical Neurology

Glutamate transporters in neurologic disease

NJ Maragakis et al.

ARCHIVES OF NEUROLOGY (2001)

Review Physiology

Extracellular calcium sensing and extracellular calcium signaling

EM Brown et al.

PHYSIOLOGICAL REVIEWS (2001)

Review Clinical Neurology

Treatment of sleep disturbance in Alzheimer's disease

SM McCurry et al.

SLEEP MEDICINE REVIEWS (2000)

Article Medicine, Research & Experimental

Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway

DE Kang et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Cell Biology

Regulation of secretion of PTHrP by Ca2+-sensing receptor in human astrocytes, astrocytomas, and meningiomas

N Chattopadhyay et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)

Article Multidisciplinary Sciences

Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure

M von Bergen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Immunology

PU.1 expression in microglia

MR Walton et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)