Journal
MOLECULAR CELL
Volume 79, Issue 6, Pages 881-901Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2020.07.003
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Funding
- Office of the Provost
- Center for Advanced Imaging at Harvard University
- National Institutes of Health (NIH) NIGMS [R00GM130896]
- Allen Distinguished Investigator Program through the Paul G. Allen Frontiers Group
- NIH New Innovator Award (DP2)
- MBL Physiology Course 2019
- National Institutes of Health [NIH GM044794]
- NIH [GM 025326]
- Pathway to Independence Award NIGMS [K99GM123195]
- Office of the NIH Director [1DP5OD023111-01]
- JSPS
- Harvard University
- Faculty of Arts Sciences
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Nucleosomes package genomic DNA into chromatin. By regulating DNA access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most nuclear processes. In addition, dynamic organization of chromatin underlies both regulation of gene expression and evolution of chromosomes into individualized sister objects, which can segregate cleanly to different daughter cells at anaphase. This collaborative review shines a spotlight on technologies that will be crucial to interrogate key questions in chromatin and chromosome biology including state-of-the-art microscopy techniques, tools to physically manipulate chromatin, single-cell methods to measure chromatin accessibility, computational imaging with neural networks and analytical tools to interpret chromatin structure and dynamics. In addition, this review provides perspectives on how these tools can be applied to specific research fields such as genome stability and developmental biology and to test concepts such as phase separation of chromatin.
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