Journal
MOLECULAR CANCER
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12943-020-01224-3
Keywords
M(6)A; CircRNA; M(6)A modified circRNA; Innate immunity; Tumour
Categories
Funding
- National Natural Science Foundation of China [81972663, 81560385]
- Key Scientific Research Projects of Institutions of Higher Education in Henan Province [19A310024]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- China Postdoctoral Science Foundation [2019 T120648, 2017 M610462]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
- Key Scientific Research Project of Henan Higher Education Institutions [20A310024]
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N-6-methyladenosine (m(6)A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m(6)A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m(6)A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m(6)A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field.
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