Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 31, Issue 13, Pages 1315-1323Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E18-10-0636
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Funding
- National Institutes of Health (NIH) [R01GM114401, R01GM126835]
- National Science Foundation CAREER grant [1846010]
- NIH [R01GM131004]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1846010] Funding Source: National Science Foundation
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The nuclear envelope (NE) is continuous with the endoplasmic reticulum (ER), yet the NE carries out many functions distinct from those of bulk ER. This functional specialization depends on a unique protein composition that defines NE identity and must be both established and actively maintained. The NE undergoes extensive remodeling in interphase and mitosis, so mechanisms that seal NE holes and protect its unique composition are critical for maintaining its functions. New evidence shows that closure of NE holes relies on regulated de novo lipid synthesis, providing a link between lipid metabolism and generating and maintaining NE identity. Here, we review regulation of the lipid bilayers of the NE and suggest ways to generate lipid asymmetry across the NE despite its direct continuity with the ER. We also discuss the elusive mechanism of membrane fusion during nuclear pore complex (NPC) biogenesis. We propose a model in which NPC biogenesis is carefully controlled to ensure that a permeability barrier has been established before membrane fusion, thereby avoiding a major threat to compartmentalization.
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