Journal
MICROFLUIDICS AND NANOFLUIDICS
Volume 24, Issue 9, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-020-02371-1
Keywords
Lab-on-a-chip; Off; on-chip integration strategy; Lab-on-a-CMOS; Microfluidic-PCB; In-plane optics; Organic electronics; Fluorescence detection
Funding
- European Union [643095]
- Marie Curie Actions (MSCA) [643095] Funding Source: Marie Curie Actions (MSCA)
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Successful development of a micro-total-analysis system (mu TAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.
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