Journal
MICROCHIMICA ACTA
Volume 187, Issue 8, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-020-04403-7
Keywords
CeO2@MnO2; Hydrothermal method; H2O2; Prostate-specific antigen; Electrochemical immunoassay; CeO2 nanoparticles; MnO2 nanosphere
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Funding
- Shandong Provincial Natural Science Foundation of China [ZR2016BM01]
- Horizontal Scientific Research Project of China [W15077]
- National Science Foundation for Young Scientists of China [21605094]
- Shandong Province Natural Science Institute Joint Fund [ZR2015YL006]
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A nanocomposite consisting of CeO(2)nanoparticle-decorated MnO(2)nanospheres (CeO2@MnO2) was synthesized for the first time viaa hydrothermal method. CeO2@MnO(2)was exploited to construct an electrochemical assays for detecting H(2)O(2)and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that CeO2@MnO(2)owned a better electrocatalytic effect towards H(2)O(2)reduction than pure MnO2NS and CeO2NP due to the synergistic effect between MnO2NS and CeO2NP. Under optimized conditions, CeO2@MnO2-based assay can be applied to detect H(2)O(2)in the range 1 to 3.0 x 10(3) mu mol L-1. The label-free electrochemical immunoassay based on CeO2@MnO(2)displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL(-1). The electrochemical assays also possessed acceptable sensitivity, selectivity, and stability. The study showed that CeO2@MnO(2)hold great potential as a biosensing platform and the clinical determination of tumor markers in human serum.
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