Journal
MICROCHIMICA ACTA
Volume 187, Issue 7, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-020-04317-4
Keywords
Basic drug determination; Chiral separation; Cyclodextrin; Free radical polymerization; Hybrid monoliths; One-pot approach
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Two kinds of hydroxypropyl beta-cyclodextrin nanohybrid monoliths were synthesized and applied in capillary electrochromatography with UV detection. One column was fabricated by concurrently using glycidyl methacrylate-bonded hydroxypropyl beta-cyclodextrin (GMA-HP-beta-CD), sodium 3-mercaptopropanesulphonate, and alkoxysilanes in the one-pot process. The other was prepared by free radical polymerization of GMA-HP-beta-CD, vinylmethylcyclosiloxane, ethylene dimethacrylate, and 2-acrylamido-2-methyl propane sulfonic acid. Compared to the former hybrid monolith, the latter one displayed improved enantiomeric separation. For ten adrenergic drugs, six anticholinergic drugs, two antidepressants, six azoles, and one antihistamine enantiomeric separation was obtained on the monolith synthesized by free radical polymerization. Twelve out of twenty-five drugs were baseline-separated. Especially, anisodamine with two chiral centers was successfully separated with resolution values of 3.06, 2.11, and 2.17. The nanohybrid monoliths were characterized by optical microscopy, scanning electron microscopy, FT-IR, nitrogen adsorption analysis, and thermogravimetric analysis. Relative standard deviation values less than 5% were obtained through run-to-run, day-to-day, and column-to-column investigations (n = 3).
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