Journal
CLINICAL NEUROLOGY AND NEUROSURGERY
Volume 151, Issue -, Pages 18-23Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.clineuro.2016.09.013
Keywords
Low grade glioma; Radiotherapy; Chemotherapy; Extent of resection; Recurrent low-grade glioma
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The importance of surgery and maximal extent of resection (EOR) is well established in primary low-grade glioma (LGG) management. However, the role of surgery in the management of recurrent LGG is less clear. A recent review on the management of recurrent LGG concluded there was insufficient evidence to recommend surgery. Here, we summarize the recent advances regarding the role of surgery, radiotherapy (RT) and chemotherapy in the management of recurrent LGG. There is increasing evidence to support maximal EOR for treating recurrent LGG, as it may improve progression free survival (PFS) after recurrence and overall survival (OS). Based on the studies presented in this review, we suggest that repeat surgery with maximal EOR should be standard of care for recurrent LGG treatment. (C) 2016 Published by Elsevier B.V.
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