Journal
MEDICINAL RESEARCH REVIEWS
Volume 40, Issue 6, Pages 2212-2289Publisher
WILEY
DOI: 10.1002/med.21703
Keywords
antitumor; berberine; biological activities; isoquinoline alkaloids
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Funding
- Key Program for International S&T Cooperation Projects of China Gansu Province [18YF1WA115]
- National Natural Science Foundation of China [21672092, 31371975, 31772790]
- National Key Research and Development Program of China [2017YFD0201404, 2016YFE0129000]
- Central Public-Interest Scientific Institution Basal Research Fund [Y2019XK14]
- NIH from the National Cancer Institute [CA177584]
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Isoquinoline alkaloids, an important class ofN-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.
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