Journal
BMC CANCER
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12885-015-1906-5
Keywords
Clear cell renal cell carcinoma; beta-Galactoside alpha-2,3-Sialyltransferase 1; Prognosis; Nomogram; Overall survival; Disease free survival
Categories
Funding
- National Natural Science Foundation of China [31100629, 31270863, 81471621, 81472227, 81472376]
- Program for New Century Excellent Talents in University [NCET-13-0146]
- Shanghai Health and Family Planning Commission [14ZR1406300]
- Shanghai Rising-Star Program [13QA1400300]
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Background: Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid in an alpha-2,3 linkage to Gal beta 1,3 GalNAc, preforms an important role in modulating cellular behaviors. However, little is known about prognostic significance of ST3GAL-1 in clear cell renal cell carcinoma (ccRCC). In this study, we aimed to investigate the prognostic significance of sialyltransferase ST3GAL-1 and its correlation with clinical outcomes in patients with ccRCC. Methods: A total of 286 patients who underwent nephrectomy between 2005 and 2007 in a single academic center were recruited. Immunohistochemical staining was performed on tissue microarrays to assess the expression level. Kaplan-Meier method and Cox proportional hazard model were applied to assess the prognostic value of ST3GAL-1. Nomograms were generated as prediction model for overall survival and disease free survival at 5 and 8 years after nephrectomy. Results: The present results show high expression of ST3GAL-1 is associated with reduced overall survival (p = 0.013) and disease free survival (p = 0.004). In multivariate cox analyses, ST3GAL-1 was defined as an independent prognostic factor for overall survival (p = 0.006) and disease free survival (p = 0.001). After incorporation into the University of California Integrated Staging System (UISS) intermediate/high risk group for non-metastatic ccRCC, ST3GAL-1 could further distinguish patient with dismal prognosis (p = 0.015 and 0.002 for OS and DFS respectively). The nomograms revealed better predictive accuracy in predicting 5- and 8-year overall survival and disease free survival than the TNM stage alone. Conclusions: ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with ccRCC.
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