Journal
MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK
Volume 51, Issue 7, Pages 850-855Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mawe.201900163
Keywords
Poly (vinyl alcohol); sodium alginate; hydrogel; controlled release; pH-sensitivity
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Poly (vinyl alcohol)/sodium alginate hydrogels were prepared by freeze-thaw followed by calcium ion crosslinking. Chloramphenicol release behavior from the poly (vinyl alcohol)/sodium alginate hydrogels in mimic conditions of gastrointestinal tract was examined. The effects of composition, number of freeze-thaw cycles and calcium ion concentration on drug release process were investigated. The results showed that the cumulative release amount of chloramphenicol from the hydrogels (crosslinked through 4 freeze-thaw cycles and immersed in 2 % calcium chloride solution) decreased from 84.3 % to 72.3 % as sodium alginate content increased from 0 % to 75 %. For the hydrogels containing 50 % sodium alginate and immersed in 2 % calcium chloride solution after the freeze-thaw cycles, cumulative release amount of chloramphenicol decreased from 83.5 % to 76.6 % as the freeze-thaw cycles increased from 2 to 6. Cumulative release amount of chloramphenicol from the hydrogels containing 50 % sodium alginate and with 4 freeze-thaw cycles decreased from 79.8 % to 75.6 % when concentration of calcium chloride solution increased from 1 % to 4 %.
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