Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 118, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111352
Keywords
Osteoarthritis; Glucosamine; Thermosensitive hydrogel; Poloxamer; Intra-articular injection
Categories
Funding
- Subprojects of Key R&D Program of the Ministry of Science and Technology [2016YFD0501000]
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This study successfully treated osteoarthritis in rabbits using thermosensitive hydrogels loaded with glucosamine, demonstrating good temperature sensitivity and therapeutic effect.
Glucosamine (GlcN) is a common drug used to treat osteoarthritis (OA). To prolong the action time of glucosamine on OA and improve its therapeutic effect, this research explored the potential application of GlcN-loaded thermosensitive hydrogels based on poloxamer 407 and poloxamer 188 for OA therapy by intra-articular injection. The thermosensitive hydrogels were prepared by cold method, and the effects of P407, P188, and GlcN on sol-gel transition temperature (Tsol-gel) were compared. After screening was performed, the optimized formulation showed good temperature sensitivity, and Tsol-gel was approximately 35 degrees C. In vitro release tests showed that GlcN was slowly released from the thermosensitive hydrogels. After the gels were intra-articularly administered to treat OA in rabbits, the degree of swelling and inflammatory factors were significantly decreased in the hydrogel group compared with those in the OA model group (P < 0.05). Histological results showed that the GlcN-administered group had a good repair effect on damaged cartilage. At the same dose, the effect of the thermosensitive hydrogels was better than that of the aqueous solution. Therefore, GlcN-loaded thermosensitive hydrogels based on poloxamers are promising sustainable delivery systems for OA therapy by intra-articular injection.
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