Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 118, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111334
Keywords
Fused deposition modeling; Bone tissue engineering; Composite; Polymer; Hydroxyapatite
Categories
Funding
- Region Ile de France through the SESAME project
- FEDER
- Region Aquitaine
- Agence Nationale de la Recherche [ANR-16-CE18-0009-01]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE18-0009] Funding Source: Agence Nationale de la Recherche (ANR)
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This study developed a composite material using medical grade PLGA mixed with nHA for manufacturing 3D porous scaffolds. The results showed that the composite scaffolds had good reproducibility, biocompatibility, and promoted osteodifferentiation in vitro.
Additive manufacturing is a rising field in bone tissue engineering. Additive fabrication offers reproducibility, high precision and rapid manufacture of custom patient-specific scaffolds. The development of appropriate composite materials for biomedical applications is critical to reach clinical application of these novel biomaterials. In this work, medical grade poly(lactic-co-glycolic) acid (PLGA) was mixed with hydroxyapatite nanoparticles (nHA) to fabricate 3D porous scaffolds by Fused Deposition Modeling. We have first confirmed that the composite material could be printed in a reproductive manner. Physical characterization demonstrated a low degradation of the material during manufacturing steps and an expected loading and homogeneous distribution of nHA. In vitro biodegradation of the scaffolds showed modifications of morphological and physicochemical properties over time. The composite scaffolds were biocompatible and high cell viability was observed in vitro, as well as a maintain of cell proliferation. As expected, the addition of nHA displayed a positive impact on osteodifferentiation in vitro. Furthermore, a limited inflammatory reaction was observed after subcutaneous implantation of the materials in the rat. Overall, this study suggests that this composite material is suitable for bone tissue engineering applications.
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