Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 112, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.110892
Keywords
Magnesium; Strontium; Bioceramic; Bone regeneration; Cell response
Categories
Funding
- Pearl River S&T Nova Program of Guangzhou [201710010149]
- Jihua Laboratory Project of Guangdong Province [X190061UZ190, KLBEMGD202001]
- Open Project of Key Laboratory of Biomedical Engineering of Guangdong Province [KLBEMGD202001]
- Open Project of National Engineering Research Center for Tissue Restoration Reconstruction [NERC-TRR202001]
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Magnesium and strontium are able to enhance osteogenesis and suppress osteoclastic activities simultaneously, and they were nontoxic in wide concentration ranges; these make the magnesium-strontium phosphate bioceramics suitable for treating osteoporotic bone defects. The aim of this study was to investigate the effects of strontium amount on the mechanical strength and cell-biological performance of magnesium-strontium phosphate [MgxSr3-x(PO4)(2); 3-x = 0, 0.1, 0.25, 0.5, 0.75, 1] bioceramics, which were sintered at 1100 degrees C. The results indicated that the magnesium-strontium phosphate bioceramics except Mg2.9Sr0.1(PO4)(2) and Mg2.25Sr0.75(PO4)(2) bioceramics had considerable compressive strength. The variation in magnesium and strontium contents did not regularly affect the in vitro osteogenic differentiation and osteoclastic activities. The Mg2.75Sr0.25(PO4)(2) bioceramic had the most desirable overall performance, as reflected by considerably high compressive strength, enhanced in vitro osteogenesis and inhibited osteoclastic activities. Therefore, the Mg2.75Sr0.25(PO4)(2) bioceramic is considered a promising biomaterial for osteoporotic bone regeneration.
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