Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 111, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.110833
Keywords
Graphene; Long-lasting antibacterial; TPU; Broad spectrum antibacterial; Wound dressing
Categories
Funding
- National Natural Science Foundation of China [51703143, 81801915]
- International Cooperation Project of Sichuan Province [2019YFH0135]
- Fundamental Research Funds for the Central Universities [YJ201707]
- State Key Laboratory of Polymer Materials Engineering of Sichuan University [sklpme2019-2-13]
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In order to obtain a novel multifunctional wound dressing with good water vapor permeability and long-lasting antibacterial properties, a skin-like thermoplastic polyurethane (TPU) bilayer membrane containing self-made polyhexamethylene guanidine hydrochloride (PHMG) grafted graphene oxide (MGO) was prepared by nonsolvent phase separation and particle filtration. The antibacterial properties and wound-healing ability of TPU, GO-TPU, MGO-TPU composite porous membrane are systematically compared. The results show that with the incorporation of MGO, the porous MGO-TPU membrane exhibits good biocompatibility, excellent water vapor transmission properties, and long-lasting broad-spectrum antibacterial properties (the antibacterial property remains unchanged for 30 days under continuously shaking and washing). The wound healing results for mouse model show that MGO-TPU could significantly accelerate the healing rate of wounds as it provides a sterile environment and also promotes the formation of re-epithelialization during wound healing.
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