Polyurethane-modified graphene oxide composite bilayer wound dressing with long-lasting antibacterial effect

In order to obtain a novel multifunctional wound dressing with good water vapor permeability and long-lasting antibacterial properties, a skin-like thermoplastic polyurethane (TPU) bilayer membrane containing self-made polyhexamethylene guanidine hydrochloride (PHMG) grafted graphene oxide (MGO) was prepared by nonsolvent phase separation and particle filtration. The antibacterial properties and wound-healing ability of TPU, GO-TPU, MGO-TPU composite porous membrane are systematically compared. The results show that with the incorporation of MGO, the porous MGO-TPU membrane exhibits good biocompatibility, excellent water vapor transmission properties, and long-lasting broad-spectrum antibacterial properties (the antibacterial property remains unchanged for 30 days under continuously shaking and washing). The wound healing results for mouse model show that MGO-TPU could significantly accelerate the healing rate of wounds as it provides a sterile environment and also promotes the formation of re-epithelialization during wound healing.