Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 111, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.110762
Keywords
Long-term cell imaging; Near-infrared fluorescence imaging; Nanoparticles; Lysosome specific probe; Bodipy
Categories
Funding
- China Scholarship Council [201606130037]
- Fundamental Research Funds for the Central Universities [xzy012019077]
- National Natural Science Foundation of China [51903201]
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Long-term, in vivo, fluorescent cell tracking probes are useful for understanding complex cellular processes including tissue regeneration, communication, development, invasion, and cancer metastasis. A near-infrared fluorescent, water-soluble probe is particularly important for studying these biological events and processes. Herein, a lysosome specific, near-infrared Bodipy probe with increased fluorescent intensity in the acidic, lysosome environment is reported. This Bodipy probe is packaged in a nanoparticle using DSPE-PEG(2000). The resulting nanoparticle is intravenously delivered to a tumor xenograft, where the fluorescent Bodipy becomes useful for non-invasive, long-term, in vivo fluorescent tumor imaging for periods greater than 36 days. These long-term, in vitro and in vitro tracking data indicate that the described Bodipy nanoparticles hold great potential for monitoring biological processes.
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