Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 111, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.110841
Keywords
Haemostasis; Antibacterial; Hydrogel; Mesoporous silica
Categories
Funding
- National Natural Science Foundation of China [81871752, 81301538, 81572178, 81673998]
- High-level Personnel Program of Wuhan University [600400002]
- Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund [cxpy2016035]
- Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning Foundation [201540151]
- Shanghai Municipal Commission of Health and Family Planning Foundation [20124356]
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The control of massive bleeding and its related wound infection is the main challenge for both military and civilian trauma centres. In this study, a cationic superabsorbent hydrogel coordinated by mesoporous silica (CSH-MS) was synthesized by free-radical polymerization for both haemostasis and antibacterial use. The as-prepared CSH-MS has a rough surface, and its water absorption is approximately 5000%. The resultant CSH-MS1 could promote blood cell aggregation and facilitate plasma protein activation via haemadsorption, resulting in efficient blood clot formation. Furthermore, CSH-MS1 (with approximately 5.06% contents of MS) dramatically reduces bleeding time and reduces blood loss in a rat-tail amputation model. Moreover, the CSH-MSs exhibits good antibacterial activities, excellent cytocompatibility and negligible haemolysis. Therefore, CSH-MS can serve as a novel type of haemostatic material in clinical applications.
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