Journal
MARINE DRUGS
Volume 18, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/md18070359
Keywords
marine-derived fungus; Aspergillussp; metabolites; sortase A; fibronectin
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Funding
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education, Science and Technology [2018R1D1A1B07043375]
- NRF of Korea - Ministry of Science, ICT and Future Planning [2018R1A4A1021703]
- BK21 Plus Program of the Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
- National Research Foundation of Korea [2018R1D1A1B07043375] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Seven alkaloidal compounds (2-8) and one polyketide (1) were isolated from a semisolid rice culture of the marine-derived fungusAspergillussp. F452. Structures of the isolated compounds were elucidated based on spectroscopic data and comparisons with previously reported data. The alkaloidal compounds (2-8) displayed weak to moderate inhibitory activities againstStaphylococcus aureus-derived sortase A (SrtA) without affecting cell viability. Aspermytin A (1) strongly inhibited SrtA activity, with an IC(50)value of 146.0 mu M, and significantly reduced bacterial adherence to fibronectin-coated surfaces. The present results indicate that the underlying mechanism of action of compound1is associated with the inhibition of SrtA-mediatedS.aureusadhesion to fibronectin, thus potentially serving as an SrtA inhibitor.
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