Journal
MARINE DRUGS
Volume 18, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/md18070352
Keywords
Aspergillus fumigatus; genome mining; chemical diversity; antimicrobial activity; biosynthetic gene cluster; prenyltransferase
Categories
Funding
- National Natural Science Foundation of China [31430002, 81573341, 21877038, 31720103901, 31320103911]
- Open Project Funding of the State Key Laboratory of Bioreactor Engineering
- 111 Project [B18022]
- Fundamental Research Funds for the Central Universities [22221818014]
- Shandong Taishan Scholar Award
- Australian Research Council [DP160101429, LE140100119, LE120100170]
- Australian Research Council [LE120100170] Funding Source: Australian Research Council
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The marine-derived fungusAspergillusfumigatusMF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin A (2), in addition to 28 known compounds (3-30). The chemical structures were established on the basis of 1D, 2D NMR and HRESIMS spectroscopic data. This is the first report on NMR data of monomethylsulochrin-4-sulphate (4) and pseurotin H (10) as naturally occurring compounds. Compounds15,16,20,23, and30displayed weak antibacterial activity (minimum inhibitory concentration: 100 mu g/mL). Compounds18and19exhibited strong activity againstS. aureus(minimum inhibitory concentration: 6.25 and 3.13 mu g/mL, respectively) andE. coli(minimum inhibitory concentration: 6.25 and 3.13 mu g/mL, respectively). A genomic data analysis revealed the putative biosynthetic gene clustersftmfor fumitremorgins,psofor pseurotins,fgafor fumigaclavines, andhelfor helvolinic acid. These putative biosynthetic gene clusters fundamentally underpinned the enzymatic and mechanistic function study for the biosynthesis of these compounds. The current study reported two new compounds and biosynthetic gene clusters of fumitremorgins, pseurotins, fumigaclavines and helvolinic acid fromAspergillusfumigatusMF071.
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