Journal
MACROMOLECULAR BIOSCIENCE
Volume 20, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202000152
Keywords
drug delivery; hydrogel; ion exchange controlled release; polymerized ionic liquids; sterilization
Funding
- Federal Ministry of Education and Research within RESPONSE Partnership for Innovation in Implant Technology [FKZ 03ZZ0910B]
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In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.
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