Mean Platelet Volume Could Reflect Disease Activity of Adult Patients With Systemic Lupus Erythematosus

Background: In recent years, research regarding mean platelet volume (MPV) has been expanded to numerous diseases. The aim of the present study was to assess whether MPV could reflect disease activity of adult patients with systemic lupus erythematosus (SLE). Methods: A total of 128 adult patients with SLE were enrolled in the present study and allocated into two subgroups (99 with active phase and 29 with inactive phase) according to SLE disease activity index (SLEDAI). Demographic data, MPV, complement 3 (C3), and complement 4 (C4) were recorded. Independent sample t-test was used for comparison of quantitative variables between the active and inactive groups. Pearson's correlation test was used to evaluate the correlation between the above laboratory indices and the SLEDAI score. Results: The mean MPV level in active patients was significantly higher than inactive subjects (8.3 +/- 1.3 vs. 7.7 +/- 0.7, p < 0.001). The correlation between MPV level and SLEDAI score was moderate (r = 0.520, p < 0.001). Conclusions: MPV might be a promising marker to reflect disease activity of adult patients with SLE.