4.2 Article

Bentonite Catalyzed an Efficient and Green Synthesis of Arylidene Meldrum's Acid Derivatives in Aqueous Media

Journal

LETTERS IN ORGANIC CHEMISTRY
Volume 18, Issue 7, Pages 513-519

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570178617999200807155325

Keywords

Knoevenagel condensation; aqueous media; natural catalyst; Arylidene Meldrum's acid; Bentonite (Al2O3 center dot 4SiO center dot H-2); electron-donating

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The paper presents a green, efficient method for the Knoevenagel condensation reaction using water as the solvent, bentonite as the catalyst, and elimination of the need for column purification of products.
In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum's acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available non-toxic mineral catalyst exposed to aqueous media under green conditions. Together with the substitution protocol of electron-donating or -withdrawing groups, all reactions were finalized from 5 to 120 min in water at 90 degrees C. With regard to such reactions, the purification of columns on products was not a requirement. Considering the environmental aspect, use of water as a green solvent, utilization of a reusable catalyst, simple work-up process and steps, as well as rapid reaction times were taken into account as some characteristics of these chemical reactions.

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