Journal
KIDNEY INTERNATIONAL
Volume 98, Issue 5, Pages 1135-1148Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2020.05.053
Keywords
C3 glomerulopathy; complement; Ig-mediated membranoproliferative glomerulonephritis
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In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, classification, clinical course, relevance of biomarkers and of pathology findings, and assessment of the efficacy of the available therapies. The present review discusses the impact of these uncertainties on the clinical management of patients.
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