4.8 Article

Arylphosphonate-Directed Ortho C-H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 28, Pages 11988-11992

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c04159

Keywords

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Funding

  1. University of Delaware (UD)
  2. University of San Diego (USD)
  3. Camille and Henry Dreyfus Foundation
  4. National Science Foundation [CHE-1800011, CHE1764307]
  5. NSF [CHE-0421224, CHE-1048367, CHE-0840401]
  6. NIH [P20GM104316, P30GM110758, S10RR02692, S10OD016267]

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Phosphonate-directed ortho C-H borylation of aromatic phosphonates is reported. Using simple starting materials and commercially accessible catalysts, this method provides steady access to o-phosphonate arylboronic esters bearing pendant functionality and flexible substitution patterns. These products serve as flexible precursors for a variety of highly substituted phosphoarenes, and in situ downstream functionalization of the products is described.

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