4.7 Article

Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System

Journal

CLINICAL INFECTIOUS DISEASES
Volume 64, Issue 9, Pages 1268-1270

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciw864

Keywords

gyrA; Neisseria gonorrhoeae; ciprofloxacin; antibiotic resistance

Funding

  1. David Geffen School of Medicine at UCLA
  2. National Institutes of Health [R21AI117256, R21AI109005]

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Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.

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