Journal
CLINICAL INFECTIOUS DISEASES
Volume 63, Issue 10, Pages 1361-1367Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciw494
Keywords
molecular diagnostics; respiratory; gastrointestinal; meningoencephalitis
Categories
Funding
- National Institutes of Health
- BioFire Dignostics, LLC [5R43AI104029-02, 5R01AI11703502]
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The development and implementation of highly multiplexed molecular diagnostic tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a variety of pathogens directly in clinical specimens. Current US Food and Drug Administration-approved multiplex panels target multiple different organisms simultaneously and can identify the most common pathogens implicated in respiratory viral, gastrointestinal, or central nervous system infections. This review summarizes the test characteristics of available assays, highlights the advantages and limitations of multiplex technology for infectious diseases, and discusses potential utilization of these new tests in clinical practice.
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