Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 11, Issue 14, Pages 5756-5762Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.0c01084
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- Japan Society for the Promotion of Science (JSPS)
- JSPS Core-to-Core Program
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Water inside and between cells with dimensions on the order of 10(1)-10(3) nm such as synaptic clefts and mitochondria is thought to be important to biological functions, such as signal transmissions and energy production. However, the characterization of water in such spaces has been difficult owing to the small size and complexity of cellular environments. To this end, we proposed and fabricated a biomimetic nanospace exploiting nanofluidic channels with defined dimensions of hundreds of nanometers and controlled environments. A method of modifying a glass nanochannel with a unilamellar lipid bilayer was developed. We revealed that 2.1-5.6 times higher viscosity of water arises in a 200 nm sized biomimetic nanospace by interactions between water molecules and the lipid bilayer surface and significantly affects the molecular/ion transport that is required for the biological functions. The proposed method provides both a technical breakthrough and new findings to the fields of physical chemistry and biology.
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