Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 144, Issue 2, Pages 89-93Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2020.07.003
Keywords
GPR143; Nicotine; Polymorphism; Addiction
Categories
Funding
- JSPS KAKENHI [JP16H06276]
- Japanese SRF Grant for Biomedical Research [1565, 117]
- Specific Research of SRF
- [18H02580]
- [18K14923]
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L-3,4-dihydroxyphenylalanine (L-DOPA) is a candidate neurotransmitter. L-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for L-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and smoking behaviors revealed that the single-nucleotide polymorphism rs6640499, in the GPR143 gene, was associated with traits of smoking behaviors in Japanese individuals. In Gpr143 gene-deficient mice, nicotine-induced hypolocomotion and rewarding effect were attenuated compared to those in wild-type mice. Our findings suggest the involvement of GPR143 in the smoking behaviors. (c) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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