Journal
CLINICAL IMAGING
Volume 40, Issue 5, Pages 1009-1013Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2016.05.009
Keywords
Brain; Maturation; Microstructure; Diffusion tensor imaging; Magnetic resonance imaging; Pediatrics
Funding
- National Institutes of Health [T32 EB001631, R01 EB9756, HD 72074, NS 046432, NS 35902]
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Purpose: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. Methods: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. Results: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. Conclusion: NODDI may allow more detailed characterization of microstructural maturation than FA. (C) 2016 Elsevier Inc. All rights reserved.
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