Journal
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Volume 45, Issue 2, Pages 267-276Publisher
WILEY
DOI: 10.1002/jpen.1970
Keywords
adult; diabetes; enteral nutrition; outcomes research; quality; renal disease
Categories
Funding
- National Institute for Health Research (NIHR)
- Health Education England (HEE) Clinical Lectureship
- NIHR
- HEE
Ask authors/readers for more resources
A renal-specific oral nutritional supplement drink results in a lower postprandial glucose response in patients with diabetes undergoing hemodialysis compared to macronutrient-matched or standard ONS options.
Background Diabetes and malnutrition are common in patients with kidney failure. We aimed to evaluate the postprandial glucose response to oral nutritional supplement drinks (ONSs) in patients with diabetes undergoing hemodialysis treatment. Methods A randomized, single-blind crossover study was conducted in patients with diabetes, and requiring chronic hemodialysis. Patients consumed either a renal-specific ONS, macronutrient-matched ONS, or standard ONS on 3 separate study days, during dialysis, following an overnight fast. Blood was collected before and 15, 30, 45, 60, 90, 120, and 180 minutes post ingestion. Mean net incremental area under the curve (iAUC) and peak incremental blood glucose concentration were compared across conditions, using analyses of variance. Results Consumption of the renal-specific ONS resulted in the lowest mean net iAUC (87.9 +/- 169.0 mmol/L per 3 hours) compared with macronutrient-matched (188.0 +/- 127.5 mmol/L per 3 hours) and standard ONS (199.5 +/- 169.2 mmol/L per 3 hours) (F-2,F-30= 5.115,P= 0.012, partial n(2)= 0.254). Pairwise comparisons demonstrated a mean difference of 100.1 mmol/L per 3 hours (95% CI, -2.8 to 202.9) in mean iAUC between the renal-specific ONS and macronutrient-matched ONS (P= 0.058). Peak blood glucose concentration, corrected for baseline, was significantly lower after the renal-specific ONS (1.40 +/- 1.0 mmol/L) compared with both macronutrient-matched (2.02 +/- 0.71 mmol/L,P= 0.036) and standard ONS (2.3 +/- 1.06 mmol/L,P= 0.017). Conclusion A renal-specific ONS elicits a lower postprandial glucose response than either macronutrient-matched ONS or standard ONS in patients with diabetes during hemodialysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available