Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 916, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2020.121265
Keywords
SAHA analogue; Hydroxamate; Bimetallic; Anticancer; Enzyme inhibition; Cobalt; Ruthenium
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Funding
- EU - European Regional Development Fund [GINOP-2.3.2-15-2016-00008]
- Hungarian Scientific Research Fund [OTKA K112317]
- Czech Science Foundation [18-09502S]
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A novel ambidentate type hydroxamic acid derivative (phenhaH, 1) containing an (O,O) and a 1,10-phenantroline (phen) based (N,N) donoratom set together with its heterobimetallic complexes incorporating an octahedral [Co(4 N)](3+) (4 N = tris(2-aminoethyl)amine (tren) or tris(2-methylpyridyl)amine (tpa)) and a half-sandwich type [(eta(6)-p-cym)Ru](2+) entity have been synthesized and characterized using various analytical techniques. Reaction of [Co(4 N)Cl]Cl-2 with 1 proved the exclusive (O,O) coordination of the ligand to the [Co( 4 N)](3+) core to yield [Co(tpa)(phenha)](ClO4)(2), (2). Subsequent treatment of 1 with [Ru(eta(6)-p-cym)Cl-2](2) and [Co(4 N)Cl]Cl-2 in a one-pot reaction resulted in the formation of [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tren)]Cl(PF6)(2) (3) and [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tpa)](PF6)(3) (4) in which the organometallic Ru core is coordinated by the phen part while the Co entity by the hydroxamate part of 1. Cyclic voltammetry revealed that 4 could be reduced at a less negative potential and exhibits a reversible Co(III)/Co(II) redox process compared to 3 due to the pi-back bonding interaction between the Co(III) centre and the pyridyl-N donors of tpa in 4. Complexes 2-4 were tested for their in vitro cytotoxicity using human-derived cancer cell lines (HeLa, MCF-7, HCT116 and MDA-MB-231) and showed moderate anti-proliferative activity in the double digit micromolar concentration range, 4 being the most active. Complex 4 displayed better activity against MDA-MB-231 cells than cisplatin. (C) 2020 The Authors. Published by Elsevier B.V.
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