Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 15, Pages 9491-9502Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03479
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Funding
- National Key Research and Development Program of China [2017YFB0307200]
- National Natural Science Foundation of China [21402176]
- Natural Science Foundation of Zhejiang Province [LY14B020003]
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The functionalization of indoles in the carbocyclic ring has been achieved via organocatalytic enantioselective Friedel-Crafts benzhydrylation of hydroxyindoles with in situ generated ortho-quinomethanes in oil-water biphases, allowing an efficient access to varied diarylindolylmethanes with a wide substrate scope. The high yields, excellent stereoselectivities, mild conditions, low catalyst loading, and easy scalability also demonstrated the interest of this novel methodology.
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