Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 16, Pages 10806-10812Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01312
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Funding
- National Natural Science Foundation of China [81673325]
- National Key Research and Development Project [2018YFE0182500]
- Gansu Province Key International S&T Cooperation Project [18YF1WA127]
- CAS Light of West China Program
- Drug Innovation Major Project [2018ZX09711001]
- CAS Pioneer Hundred Talents Program
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Bungsteroid A (1), possessing an unreported carbon skeleton, was isolated from the pericarps of Zanthoxylum bungeanum Maxim. It represents the first carbon skeleton of a C-34 steroid analogue featuring a unique 6/6/6/6/5-fused pentacyclic skeleton, which has been determined by spectroscopic methods, quantum-chemical C-13 NMR, ECD calculations, and calculations of optical rotations. Bungsteroid A showed the antiproliferative effects against HepG2, MCF-7, and HeLa cell lines with the IC50 values of 56.3 +/- 1.1, 64.2 +/- 0.9, and 74.2 +/- 1.3 mu M, respectively.
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