Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 14, Pages 9244-9254Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01237
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Funding
- CSIR, New Delhi [MLP0148, MLP0154]
- UGC, New Delhi
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A cobalt(III)-catalyzed C-8 selective C-H amidation of quinoline N-oxide using dioxazolone as an amidating reagent under mild conditions is disclosed. The reaction proceeds efficiently with excellent functional group compatibility. The utility of the current method is demonstrated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated product into functionalized quinolines. Furthermore, the developed catalytic method is also applicable for C-7 amidation of N-pyrimidylindolines and ortho-amidation of benzamides.
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