Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 79, Issue 7, Pages 719-733Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nlaa046
Keywords
Inflammatory myopathy; Muscle biopsy; Muscular dystrophy; Myopathy; Neurogenic atrophy
Categories
Funding
- NIH (NINDS) [U54, NS053672]
- Iowa Wellstone Muscular Dystrophy Cooperative Research Center
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Competence in muscle biopsy evaluation is a core component of neuropathology practice. The practicing neuropathologist should be able to prepare frozen sections of muscle biopsies with minimal artifacts and identify key histopathologic features of neuromuscular disease in hematoxylin and eosin-stained sections as well as implement and interpret a basic panel of additional histochemical, enzyme histochemical, and immunohistochemical stains. Important to everyday practice is a working knowledge of normal muscle histology at different ages, muscle motor units, pitfalls of myotendinous junctions, nonpathologic variations encountered at traditional and nontraditional muscle sites, the pathophysiology of myonecrosis and regeneration, and approaches to distinguish muscular dystrophies from inflammatory myopathies and other necrotizing myopathies. Here, we provide a brief overview of what every neuropathologist needs to know concerning the muscle biopsy.
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