Journal
JOURNAL OF NEUROLOGY
Volume 267, Issue 12, Pages 3741-3752Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-020-10044-w
Keywords
Fabry disease; Biomarkers; lysoGb3; Oxidative stress
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Funding
- University of Pisa within the CRUI-CARE Agreement
- Shire International GmbH, a Takeda company [IIR-ITA-001466]
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Background Fabry disease (FD) is an X-linked lysosomal storage disorder, caused by deficient activity of the alpha-galactosidase A enzyme leading to progressive and multisystemic accumulation of globotriaosylceramide. Recent data point toward oxidative stress signalling which could play an important role in both pathophysiology and disease progression. Methods We have examined oxidative stress biomarkers [Advanced Oxidation Protein Products (AOPP), Ferric Reducing Antioxidant Power (FRAP), thiolic groups] in blood samples from 60 patients and 77 healthy controls. Results AOPP levels were higher in patients than in controls (p < 0.00001) and patients presented decreased levels of antioxidant defences (FRAP and thiols) with respect to controls (p < 0.00001). In a small group of eight treatment-naive subjects with FD-related mutations, we found altered levels of oxidative stress parameters and incipient signs of organ damage despite normal lyso-Gb3 levels. Conclusions Oxidative stress occurs in FD in both treated and naive patients, highlighting the need of further research in oxidative stress-targeted therapies. Furthermore, we found that oxidative stress biomarkers may represent early markers of disease in treatment-naive patients with a potential role in helping interpretation of FD-related mutations and time to treatment decision.
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