Journal
JOURNAL OF NEUROGENETICS
Volume 34, Issue 3-4, Pages 518-526Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/01677063.2020.1781849
Keywords
C; elegans; aging; temperature; thermosensory neurons; lipid signaling
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Funding
- Korean Government (MSICT) through the National Research Foundation of Korea (NRF) [NRF2019R1A3B2067745]
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Temperature affects animal physiology, including aging and lifespan. How temperature and biological systems interact to influence aging and lifespan has been investigated using model organisms, including the nematodeCaenorhabditis elegans. In this review, we discuss mechanisms by which diverse cellular factors modulate the effects of ambient temperatures on aging and lifespan inC. elegans. C. elegansthermosensory neurons alleviate lifespan-shortening effects of high temperatures via sterol endocrine signaling and probably through systemic regulation of cytosolic proteostasis. At low temperatures,C. elegansdisplays a long lifespan by upregulating the cold-sensing TRPA channel, lipid homeostasis, germline-mediated prostaglandin signaling, and autophagy. In addition, co-chaperone p23 amplifies lifespan changes affected by high and low temperatures. Our review summarizes how external temperatures modulateC. eleganslifespan and provides information regarding responses of biological processes to temperature changes, which may affect health and aging at an organism level.
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