Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 7, Pages 2200-2206Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00298
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Funding
- Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Science Fund for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [31370372, 81573316, 21702067, 31900289]
- Academic Frontier Youth Team of HUST
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
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Five new drimane-type sesquiterpenoids, named proversilins A-E (1-5), were isolated from the endophytic fungus Aspergillus versicolor F210 isolated from the bulbs of Lycoris radiata. Their structures and absolute configurations were characterized by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data, comparison of experimental and calculated electronic circular dichroism data, and X-ray crystallography. Proversilins B-E (2-5) represent the first examples of natural products featuring an N-acetyl-beta-phenylalanine moiety. Compounds 3 and 5 inhibited the growth of HL-60 cells with IC50 values of 7.3 and 9.9 mu M, respectively.
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