Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 7, Pages 2233-2240Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00344
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Funding
- Daniel K. Inouye College of Pharmacy (DKICP)
- University of Hawaii at Hilo (UHH)
- Victoria S. and Bradley L. Geist Foundation [15ADVC-74420, 17CON-86295]
- Hawaii IDeA Network for Biomedical Research Excellence III and IV (INBRE-III and INBRE-IV) project NIGMS [5P20GM103466]
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Five new lumazine peptides (1-5), a new aspochalasin derivative (6), and a new y-butyrolactone derivative (7), together with seven known compounds (8-14), were isolated from a Hawaiian fungal strain, Aspergillus flavipes FS888. Compound 1 is an uncommon natural product containing an isocyano group. The structures of the new compounds 1-7 were elucidated by NMR spectroscopy, HRESIMS, chemical derivatization, and ECD analysis. Compounds 12-14 showed significant antibacterial activity against S. aureus when in combination with disulfiram. Additionally, compounds 9 and 13 showed NF-kappa B inhibitory activity with IC50 values of 3.1 +/- 1.0 and 10.3 +/- 2.0 mu M, respectively.
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