Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 8, Pages 2330-2336Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01169
Keywords
-
Funding
- Investissement d'Avenir grant by Agence Nationale de la Recherche (CEBA) [ANR-10-LABX-25-01]
Ask authors/readers for more resources
Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1-13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC50 values in the 10 to 20 mu M range without cytotoxicity. None inhibited Zika virus NS5 protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available