4.7 Article

Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 8, Pages 2330-2336

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01169

Keywords

-

Funding

  1. Investissement d'Avenir grant by Agence Nationale de la Recherche (CEBA) [ANR-10-LABX-25-01]

Ask authors/readers for more resources

Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1-13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC50 values in the 10 to 20 mu M range without cytotoxicity. None inhibited Zika virus NS5 protein.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available